The mechanism of action

The mechanism of action is based on the local effect of tannins (trypins - plant metabolites from the group of polyphenols) that coagulate proteins. This effect of tannins (oligomeric proanthocyanidins) consists of crosslinking the polyhydroxyphenol groups of tannins with cell surface proteins, which causes sealing and wrinkling of the surface of the skin, followed by strengthening and strengthening of vascular walls with styptic and / hemostatic effect. Tannins act anti-phlogistically - by reducing inflammation of the skin, mucous membranes and wounds, and also antibacterially and antivirally by coagulating microbial proteins to prevent the formation of microorganisms at the wound site.

Flavonoids (diosmin and hesperidin), by reducing capillary fragility and microcirculation, form microenvironment of wounds to promote beneficial antioxidant, antibacterial and anti-inflammatory effects of tannins.

Medical device RECTOVENAL® Acute with tannins from Quercus robur extract and flavonoids (diosmin and hesperidin) helps the hemorrhoid healing process in the anorectal area by facilitating wound regeneration and regeneration by controlling its microenvironment.

The synergistic effect of tannins and flavonoids results in relief from primary symptoms of the disease such as - irritation, itching, burning, oozing, bleeding at the affected site in the anorectal area.

Medical device RECTOVENAL® Acute = 2 Active ingredients + pharmaceutical benefit:

1 Oak bark extract:

Active substance-tannins (plant metabolites from the group of polyphenols)

Adstringent effect = complex local effect →

Coagulation and aggregation of mucous membrane proteins / skin → formation of protective coating:

  • crosslinking of polyhydroxyphenol groups of tannins with surface proteins of mucous membranes / skin cells
  • sealing and wrinkling of the surface of the mucous membrane / skin with strengthening and strengthening vessel wall

Effect of protective layer:

  • Hemostatic - stops bleeding (by coagulating the proteins - by sealing the surface of the mucous membrane) skin)
  • Re-epithelial - promotes recovery and wound healing by forming a still environment - supporting the creation of new skin tissue (granulation, epithelization)
  • Anti-nflammatory - reduces inflammation (inflammation arises as a consequence of the defensive mechanism of the organism on the wound)
  • Anti-edema - relieves swelling (swelling arises from inflammation, accumulation of blood as a consequence of enlargement and increased vasoconstriction)
  • Antioxidant - tannins and tannin complexes - protein (they bind to their chemical structures) reactive forms of oxygen (ROS)
  • Anti-bacterial (antiviral) antiseptic - prevents the penetration and formation of microorganisms at the wound site

2 Flavonoids

Active substance = diosmin and hesperidin (flavonoids/bioflavonoids)

Flebotropic / Vazoprotective effect = targeted effect on venous plexus

  • Positive effect on microcirculation (capillary blood flow)
    • reduce capillary hyperpermeability (increased permeability)
    • reduce capillary fragility (brittleness-cracking)
    • reduce blood viscosity (accelerate blood flow)
    • reduce adhesion of leukocytes (prevention of partial obstruction of the capillary lumen)
  • reduce leukocyte activation (white blood cells - activation releases reactive oxygen species - antioxidant effect)
  • Reduce the release of inflammatory mediators (anti-inflammatory effect) - suppression of chronic inflammation
  • Positive effect on macrocycling (vascular blood circulation - tissue)
    • increase vein tone (blood vessel tension = facilitate blood flow)
    • decrease capillary permeability (permeability)
    • protect endothelial cells against blood stasis (reduce swelling) preventing the onset of an inflammatory reaction (anti-inflammatory effect)

The result:

  • Restoration of natural permeability and tonus of venous plexus = natural blood circulation
  • Accumulated blood leakage = Reduction of vessel load + Reduction of swelling
  • Suppression of local (venous) inflammatory processes

By targeted mechanism of action complements the complex function of the protective layer at the wound site (hemorrhoid).

3 Hydrogel - benefit of the pharmaceutical form

  • Cross-linked polymeric gel with high water content (more than 90 %)
  • Wet wound healing = more favorable conditions than dry healing
  • Hydrogel cover helps heal wounds:
  • keeps the wet environment
  • allows the exudate absorption wound to be cleansed (depends on the wound range, ideal for wounds with moderate to moderate intensity)
  • High moisture content regulates gas permeability
  • protect against the penetration of microorganisms
  • cooling, calming effect (mild local anesthetic effect)

Rectovenal - Mechanism of action